Video

When it comes to treatment of FMF, like key goals is to effectively control attacks, prevent subclinical inflammation between attacks and avoid complications such as AA amyloidosis. Colchicine has proven to be safe and cost-effective first-line medication that is considered a milestone in treatment of FMF. The average dose for adults ranges from 1 to 2 mg, with maximum dose of 3 mg. If patient cannot tolerate this dose, then the dose should be increased only to maximum tolerated dose (Ozen S, 2016). It is worth noting that since colchicine is lifelong medication. It is important to be aware of any potential drug interactions. For FMF patients who are pregnant, colchicine can be safely used during pregnancy and also during breastfeeding without the need to reduce the dose. Furthermore, colchicine used in FMF patients has no paternal effect on pregnancy, outcomes, or complications (Ozen S, 2016). There is one more thing to emphasise. Before concluding that colchicine is ineffective, it is crucial to evaluate patient compliance. Patients must be reminded of the importance of complying with colchicine treatment as non-compliance is a common reason for poor response (Bhatt H, 2023).